MUCOADHESIVE BUCCAL PATCHES OF LORNOXICAM: I- DEVELOPMENT AND IN-VITRO CHARACTERIZATION
نویسندگان
چکیده
منابع مشابه
Development and characterization of mucoadhesive patches of salbutamol sulfate for unidirectional buccal drug delivery.
Buccal patches of salbutamol sulfate were prepared using five different water soluble polymers in various proportions and combinations using PEG-400/PG as plasticizers. A 32 full factorial design was used to design the experiments for each polymer combination. Patches were laminated on one side with a water impermeable backing layer for unidirectional drug release. The thickness of medicated pa...
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The goal of the present investigation was to design and evaluate mucoadhesive buccal patches of Cyproheptadine Hydrochloride (CPH) which is a sedating antihistamine with antimuscarinic, serotonin-antagonist, and calcium-channel blocking action. Buccal films were made with Hydroxy propylcellulose (HPC EF) and Hydroxy Propyl Methyl Cellulose (HPMC E15) as mucoadhesive polymers. Permeation of CPH ...
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The goal of the present investigation was to design and evaluate mucoadhesive buccal patches of Ondansetron Hydrochloride (OND) which is used for nausea and vomiting associated with cancer chemotherapy and radiotherapy. Permeation of OND was calculated ex vivo using porcine buccal membrane. Buccal films were developed by solvent-casting technique using Hydroxy Propyl Methyl Cellulose(HPMC E15) ...
متن کاملDesign and characterization of chitosan-containing mucoadhesive buccal patches of propranolol hydrochloride.
Mucoadhesive buccal patches containing propranolol hydrochloride were prepared using the solvent casting method. Chitosan was used as bioadhesive polymer and different ratios of chitosan to PVP K-30 were used. The patches were evaluated for their physical characteristics like mass variation, drug content uniformity, folding endurance, ex vivo mucoadhesion strength, ex vivo mucoadhesion time, su...
متن کاملChitosan Based Unidirectional Release Buccal Patches of Carbamazepine: Formulation Development and In Vitro, Ex Vivo Characterization
The unidirectional release buccal patches of carbamazepine (CBZ) were designed in total of 36 formulations using a 32 full factorial design. Different hydrophilic polymers were used in the formulation along with chitosan-HPMC matrix. The thickness of the prepared patches varied between 0.3 ± 0.10 and 0.5 ± 0.15 mm. The mass of the patches varied from 142.4 ± 0.22 and 160.2 ± 0.13 mg. The pH of ...
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ژورنال
عنوان ژورنال: Bulletin of Pharmaceutical Sciences. Assiut
سال: 2010
ISSN: 1110-0052
DOI: 10.21608/bfsa.2010.147025